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Cl-amidine hydrochloride
CAS No. 1373232-26-8
Cl-amidine hydrochloride( —— )
Catalog No. M23526 CAS No. 1373232-26-8
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
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| 10MG | 156 | In Stock |
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| 25MG | 314 | In Stock |
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| 50MG | 509 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCl-amidine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).
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DescriptionCl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
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In VitroApoptosis Analysis.Cell Line:TK6 lymphoblastoid cells and HT29 colon cancer cells. Concentration:0, 5, 10, 15, 20, 25, 50 μg/mL.Incubation Time:24 h.Result:Induced apoptosis dose-dependently.
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In VivoAnimal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis).Dosage:75 mg/kg.Administration:IP once daily.Result:Suppressed PAD activity, protein citrullination, and PAD levels in the colon in vivo.Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis). Dosage:5, 25, 75 mg/kg.Administration:Oral gavage once daily.Result:Led to significant reductions in the histology scores.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|MicroRNA|PAD4
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Research Area——
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Indication——
Chemical Information
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CAS Number1373232-26-8
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Formula Weight347.24
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Molecular FormulaC14H20Cl2N4O2
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Purity>98% (HPLC)
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SolubilityH2O:50 mg/mL (143.99 mM; Need ultrasonic);DMSO:19.23 mg/mL (55.38 mM; Need ultrasonic)
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SMILESO=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3; 45(39): 11727–11736.
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